Background:

This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

Specificity:

Collagen VI polyclonal antibody detects endogenous levels of Collagen VI protein.

Alternative names:

COL6A1, COL6A2, COL6A3, Alpha 1 (VI) chain (61 AA), CO6A1, COL6A1, COL6A2, COL6A3, Collagen alpha 2(VI) chain, Collagen alpha 3(VI) chain, Collagen alpha-1(VI) chain, Collagen type VI alpha 1, Collagen type VI alpha 2, Collagen type VI alpha 3, Collagen VI alpha 1 polypeptide, Collagen VI alpha 2 polypeptide, Collagen VI alpha 3 polypeptide, CollagenVI, Human mRNA for collagen VI alpha 2 C terminal globular domain, OPLL, PP3610,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

134/109 kDa

Applications:

WB ICC/IF IHC

Usage:

WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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