Bioworld Technology

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Claudin 5 polyclonal antibody BS90308

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Specifications

size	50ul/100ul

Background:

The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human Claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.

Specificity:

Claudin 5 polyclonal antibody detects endogenous levels of Claudin 5 protein.

Alternative names:

TMDVCF, CLDN5, Androgen withdrawal and apoptosis induced protein RVP1 like, AWAL, BEC 1, BEC1, Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome), Claudin-5, Claudin5, CLD5, CLDN 5, Cldn5, CPETR L1, CPETRL 1, CPETRL1, TMDVCF, TMVCF, Transmembrane protein deleted in VCFS, Transmembrane protein deleted in velocardiofacial syndrome,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

24 kDa

Applications:

WB IHC

Usage:

WB:1:2,000-1:5,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com