Background:

A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The evolutionarily conserved Centromere Protein-C, CENP-C, is a kinetochore assembly protein. CENP-C is located on the fibers of the kinetochore and constitutes a kinetochore organizing center that tightly associates with DNA. CENP-C is necessary for the formation of a functional centromere, which indicates that CENP-C is important for mitotic progression. In addition, CENP-C is lost from centromeres during herpes simplex virus 1 infection, causing substantial structural changes in the kinetochore, which suggests that the structure of CENP-C is regulated during the cell cycle.

Specificity:

CENPC polyclonal antibody detects endogenous levels of CENPC protein.

Alternative names:

CENP-C, CENP-C 1, CENP-C 1, CENP-C, CENPC, CENPC1, Centromere autoantigen C, Centromere autoantigen C1, Centromere protein C 1, Centromere protein C, hcp-4, ICEN7, Interphase centromere complex protein 7, MIF2,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human CENPC aa 400-600.

Purification & Purity:

ProA affinity purified

Molecular weight:

107 kDa

Applications:

WB ICC IF IHC FC IP

Usage:

WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:200 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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