Background:

Cdc5L (Cell division cycle 5-like protein, Pombe Cdc5-related protein) is a DNA-binding protein encoded by the human gene CDC5L. Cdc5L contains 2 HTH myb-type DNA-binding domains and may shuttle between cytoplasm and nucleus. It is involved in cell cycle control and may act as a transcription activator. CDC5L is a spliceosomal protein that is highly conserved across species. It is a member of a protein group that comprise the core of spliceosomal complexes and are essential for pre-mRNA splicing. Cdc5L is involved in the second catalytic step of pre-mRNA splicing, which involves cleavage at the 3' splice site and the ligation of the exons. This process releases the intact intron lariat. A chromosomal aberration involving Cdc5L is found in multicystic renal dysplasia. This aberration is caused by a translocation with USF-2.

Specificity:

CDC5L polyclonal antibody detects endogenous levels of CDC5L protein.

Alternative names:

Cdc5-like protein, CDC5L, CDC5, CDC5 cell division cycle 5-like (S. pombe), Cdc5 related protein, CDC5-LIKE, Cdc5-like protein, Cdc5l, CDC5L, CEF1, Cell division cycle 5 S. pombe homolog of, Cell division cycle 5-like protein, dJ319D22.1, KIAA0432, PCDC5RP, Pombe Cdc5 related protein, Pombe Cdc5-related protein,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

92/100 kDa

Applications:

WB ICC/IF IHC

Usage:

WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com