Background:

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with Hsp90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Specificity:

Cdc37 polyclonal antibody detects endogenous levels of Cdc37 protein.

Alternative names:

CDC37, CDC 37, Cdc37, CDC37 cell division cycle 37 homolog, CDC37 cell division cycle 37 S cerevisiae homolog, CDC37 cell division cycle 37, S cerevisiae, homolog of, Cdc37 homolog, CDC37 protein, CDC37, CDC37A, cell division cycle 37, Cell division cycle 37 homolog, Hsp90 chaperone protein kinase targeting subunit, Hsp90 chaperone protein kinase targeting subunit p50Cdc37, Hsp90 chaperone protein kinase-targeting subunit, Hsp90 co chaperone Cdc37, Hsp90 co-chaperone Cdc37, p50, p50Cdc37, S cerevisiae hypothetical protein CDC37,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

45 kDa

Applications:

WB IHC IP FC

Usage:

WB:1:1,000-1:5,000 FC:1:50-1:100 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com