Background:

Strongly expressed in human liver and pancreas, with weaker expression in heart and brain, the cytoplasmic protein cystathionine b-synthase (CBS) operates in the first step of homocysteine transulfuration. CBS, which belongs to the cysteine synthase/cystathionine b-synthase family of proteins, catalyzes the formation of cystathionine from the thrombogenic amino acid homocysteine using pyridoxal phosphate cofactor. Allosteric activation by adenosyl-methionine regulates CBS activity. Deficiencies in CBS are assoc-iated with homocystinuria, a recessively inherited error in sulfur amino acid metabolism that affects many organs and tissues. Symptoms of homocytinuria include arteriosclerosis, thrombosis, dislocated optic lenses, mental retard-ation and skeletal abnormalities.

Specificity:

CBS polyclonal antibody detects endogenous levels of CBS protein.

Alternative names:

CBS, AI047524, AI303044, Beta thionase, Beta-thionase, Cbs, Cbs cystathionine beta-synthase, CBS, Cystathionine beta synthase, Cystathionine beta-synthase, EC 4.2.1.22, HIP 4, HIP4, Methylcysteine synthase, MGC18856, MGC18895, MGC37300, OTTHUMP00000109416, OTTHUMP00000109418, Serine sulfhydrase,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human CBS aa 400-550.

Purification & Purity:

ProA affinity purified

Molecular weight:

61 kDa

Applications:

WB ICC

Usage:

WB:1:500-1:2,000 ICC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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