Background:

The complement component proteins C3, C4 and C5 are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage. These proteins belong to the α2-macroglobulin family, but retain distinctive features including an anaphylatoxin domain and a netrin (NTR) domain. The human C4 gene is polymorphic at two loci, C4A and C4B, mapping to chromosome 6p21.32. C4A expresses the Rodgers (Rg) blood group Ag, while C4B expresses the Chido (Ch) blood group Ag. C4 is expressed as a precursor that is cleaved into α, β and γ chains, all of which are non-identical cleavage products. The α chain of C4 may be cleaved to produce an acidic isotype, C4a, which reacts with amino groups, and a basic isotype, C4b, which reacts with hydroxyl groups. Deficiency in the C4 gene is associated with autoimmune or immune complex disorders, such as systemic lupus erythematosus.

Specificity:

C4 polyclonal antibody detects endogenous levels of C4 protein.

Alternative names:

C4A, CO4, CPAMD2, Acidic C4, Acidic complement C4, Basic C4, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4, Chido form, C4, Rodgers from, C4A anaphylatoxin, C4A, C4A2, C4A3, C4A4, C4A6, C4AD, C4B, C4B_2, C4B1, C4B12, C4B2, C4B3, C4BD, C4F, C4S, CH, Chido form of C4, CO4, CO4A, Complement C4 gamma chain, complement C4-A, complement C4-B, complement C4-B-like, complement C4B1a, Complement component 4A (Rodgers blood group), Complement component 4A, complement component 4B (Chido blood group), copy 2, Complement component 4B (Childo blood group), Complement component 4B, Complement component 4F, Complement component 4S, CPAMD2, CPAMD3, RG, Rodgers form of C4,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

193 kDa

Applications:

WB ICC/IF IHC

Usage:

WB:1:200-1:500 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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