Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
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BubR1 polyclonal antibody BS90152

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Specifications

size	50ul/100ul

Background:

Human cells contain two related protein kinases, BUB1 and BUBR1, that appear to have evolved from a single ancestral BUB1 gene. Both kinases are concentrated near the surface of the kinetochore where they monitor kinetochore-microtubule interactions. BUB1 and BUBR1 bind to kinetochores and are postulated to be components of the mitotic checkpoint, which monitors kinetochore activities to determine if chromosomes have achieved alignment at the spindle equator. BUBR1 is essential for normal mitotic progression as it prevents cells from prematurely entering anaphase. BUB3 is a conserved component of the mitotic spindle assembly complex and is also involved with the essential spindle checkpoint pathway that operates during early embryogenesis.

Specificity:

BubR1 polyclonal antibody detects endogenous levels of BubR1 protein.

Alternative names:

hBUBR1, BUB1B, BUBR1, MAD3L, SSK1, Beta homolg of S. cerevisiae BUB 1, Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles, BUB 1B, BUB1 budding uninhibited by benzimidazoles 1 homolog beta, Bub1A, BUB1B, BUB1B, BUB1beta, BUBR1, Budding Uninhibited by Benzimidazoles 1 beta, Budding uninhibited by benzimidazoles 1 homolog beta (yeast), hBUBR1, MAD3/BUB1 related protein kinase, MAD3/BUB1-related protein kinase, MAD3L, Mitotic checkpoint gene BUB1B, Mitotic checkpoint kinase MAD3L, Mitotic checkpoint serine/threonine protein kinase BUB1 beta, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, MVA1, OTTHUMP00000160319, Protein SSK1, SSK 1, SSK1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human BubR1 330-600 aa.

Purification & Purity:

Protein affinity purified.

Molecular weight:

119 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:5,000-1:10,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com