Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
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Bub3 polyclonal antibody BS90151

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Specifications

size	50ul/100ul

Background:

BUB3 (budding uninhibited by benzimidazoles 3 homolog), also known as BUB3L or hBUB3, is a conserved component of the mitotic spindle assembly complex (MCC). It contains five WD repeat domains and forms cell cycle constitutive complexes with BUB1 and BUBR1. BUB3 is essential for the kinetochore localization of BUB1 and BUBR1. As a component of the MCC, BUB3 is involved in the essential spindle checkpoint pathway that operates during early embryogenesis. The spindle checkpoint pathway functions to postpone the initiation of anaphase until chromosomes are properly attached to the spindle. This acts to ensure accurate chromosome segregation. In addition, BUB3 plays a role in regulating the establishment of correct kinetochore-microtubule attachments. BUB3 is also thought to bind Tctex1L (or DYNLT3), a dynein light chain.

Specificity:

Bub3 polyclonal antibody detects endogenous levels of Bub3 protein.

Alternative names:

BUB3, Aa2-050, AU019800, AU021329, AU043350, AW146323, BUB 3, BUB 3L, BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog, bub3, BUB3 budding uninhibited by benzimidazoles 3 homolog, BUB3 mitotic checkpoint protein, BUB3, BUB3L, Budding uninhibited by benomyl, Budding uninhibited by benzimidazoles 3, Budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae), Budding uninhibited by benzimidazoles 3 homolog (yeast), Budding uninhibited by benzimidazoles 3 homolog, Budding uninhibited by benzimidazoles 3, S. cerevisiae, homolog of, C78067, hBUB3, Mitotic checkpoint component, Mitotic checkpoint protein bub3, OTTHUMP00000020679, OTTHUMP00000020680, WD repeat type I transmembrane protein A72.5,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein corresponding to the N-terminus of human Bub3.

Purification & Purity:

ProA affinity purified

Molecular weight:

37 kDa

Applications:

WB ICC IF IP IHC FC

Usage:

WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 IP:1:10-1:50 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com