Background:

The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Emt (also known as Itk or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

Specificity:

BTK polyclonal antibody detects endogenous levels of BTK protein.

Alternative names:

ATK, BPK, BTK, AGMX1, ATK, BPK, Agammaglobulinaemia tyrosine kinase, AGMX 1, AGMX1, AT, ATK, B cell progenitor kinase, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, Bruton’s Tyrosine Kinase, Btk, BTK, dominant-negative kinase-deficient Brutons tyrosine kinase, IMD 1, IMD1, MGC126261, MGC126262, OTTHUMP00000063593, PSCTK 1, PSCTK1, truncated Bruton agammaglobulinemia tyrosine kinase, Tyrosine protein kinase BTK, Tyrosine-protein kinase BTK, tyrosine-protein kinase BTK isoform (lacking exon 14, XLA,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

76 kDa

Applications:

WB IP

Usage:

WB:1:1,000-1:2,000

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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