Background:

Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl10 is homologous to the equine herpesvirus-2 E10 gene and, like E10, it contains an N-terminal caspase recruitment domain (CARD). Expression of Bcl10 has been shown to induce NFκB activation in a NIK-dependent pathway, and research indicates that the CARD domain is essential for this activation; although in a separate study, Bcl10 by itself did not induce JNK or NFκB activation. Overexpression of Bcl10 has been shown to induce apoptosis in a manner dependent on CARD-mediated oligomerization. Bcl10 has also been shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas.

Specificity:

Bcl10 polyclonal antibody detects endogenous levels of Bcl10 protein.

Alternative names:

Bcl-10, hCLAP, CIPER, cCARMEN, c-E10, mE10, BCL10, AI132454, B cell CLL/lymphoma 10, B cell lymphoma/leukemia10, B-cell CLL/lymphoma 10, B-cell leukemia/lymphoma 10, B-cell lymphoma/leukemia 10, Bcl 10, Bcl-10, Bcl10, BCL10, c E10, c-E10, C81403, CARD containing apoptotic signaling protein, CARD containing molecule enhancing NF kappa B, CARD containing molecule enhancing NF kB, CARD containing molecule enhancing NF-kB, CARD containing molecule enhancing NFkB, CARD containing proapoptotic protein, CARD like apoptotic protein, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CARD-like apoptotic protein, CARMEN, Caspase recruiting domain containing protein, caspase-recruiting domain-containing protein, cCARMEN, cE 10, cE10, CED 3/ICH 1 prodomain homologous E10 like regulator, CED-3/ICH-1 prodomain homologous E10-like regulator, CED3/ICH1 prodomain homologous E10 like regulator, Cellular E10, Cellular homolog of vCARMEN, Cellular-E10, CIPER, CLAP, hCLAP, Mammalian CARD containing adapter molecule E10, Mammalian CARD-containing adapter molecule E10, mE 10, mE10, R-RCD1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

31 kDa

Applications:

WB ICC/IF IHC IP

Usage:

WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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