Background:

The SWI/SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF1 or SNF2α) and Brg-1 (also designated SNF2 or SNF2β) are the ATPase subunits of the mammalian SWI/SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI/SNF complex. In higher eukaryotes, BAF57 is also a critical component of the SWI/ SNF complex. BAF57 contains a high-mobility-group (HMG) domain adjacent to a kinesin-like region and is a DNA-binding subunit of the SWI/SNF complex. The human BAF57 gene maps within the q12-25 region of chromosome 17, a gene-rich area implicated in breast and ovarian cancers.

Specificity:

BAF57 polyclonal antibody detects endogenous levels of BAF57 protein.

Alternative names:

BAF57, SMARCE1, BAF57, BRG1 associated factor 57, BRG1-associated factor 57, Chromatin remodeling complex BRG1 associated factor 57, FLJ35648, SMARCE 1, SMARCE1, SMCE1, SWI/SNF related matrix associated actin dependent regulator of chromatin e1, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human BAF57 aa 1-200.

Purification & Purity:

ProA affinity purified

Molecular weight:

47 kDa

Applications:

WB ICC IF IHC IP

Usage:

WB:1:500-1:2,000 ICC/IF:1:50-1:200 IHC:1:50-1:200 IP:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com