Background:

ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting. It is secreted in blood and degrades large vWf multimers, decreasing their activity. Glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL.

Specificity:

ADAMTS13 polyclonal antibody detects endogenous levels of ADAMTS13 protein.

Alternative names:

ADAM-TS 13, ADAM-TS13, ADAMTS-13, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8, A disintegrin and metalloproteinase with thrombospondin motifs 13, A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13, A disintegrin like and metalloprotease with thrombospondin type 1 motif 13, ADAM metallopeptidase with thrombospondin type 1 motif 13, ADAM TS, ADAM-TS 13, ADAM-TS13, ADAMTS 13, ADAMTS-13, ADAMTS13, ADAMTS13 protein, ATS13, C9orf8, TTP, Von Willebrand factor cleaving protease, von Willebrand factor-cleaving protease, vWF cleaving protease, vWF CP, vWF-cleaving protease, vWF-CP, vWFCP,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human ADAMTS13 aa 150-350.

Purification & Purity:

ProA affinity purified

Molecular weight:

Predicted band size 154 kDa

Applications:

WB IHC FC

Usage:

WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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