Background:

Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.Isoform 1 does not display proton-gated cation channel activity.

Specificity:

ACCN2 polyclonal antibody detects endogenous levels of ACCN2 protein.

Alternative names:

ASIC1, BNaC2, ASIC1, ACCN2, BNAC2, ACCN2, ACCN2, Acid sensing ion channel 1, Acid sensing ion channel 1a protein, Acid sensing ion channel, Acid-sensing ion channel 1, AI843610, Amiloride sensitive cation channel 2 neuronal, Amiloride-sensitive cation channel 2, ASIC, ASIC1, ASIC1A, B530003N02Rik, BNaC2, Brain sodium channel 2, Cation channel amiloride sensitive neuronal 2, hBNaC2, neuronal,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide within human ACCN2 aa 460-500.

Purification & Purity:

Peptide affinity purified.

Molecular weight:

60 kDa

Applications:

WB IHC FC

Usage:

WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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