Background:

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.

Specificity:

ACC1 polyclonal antibody detects endogenous levels of ACC1 protein.

Alternative names:

ACC1, ACACA, ACAC, ACC1, ACCA, ACAC, ACACA, ACACA, ACACB, ACC alpha, ACC, ACC beta, ACC-alpha, ACC1, ACC2, ACCA, ACCB, Acetyl CoA carboxylase 1, Acetyl CoA carboxylase 2, Acetyl CoA carboxylase alpha, Acetyl CoA carboxylase beta, Acetyl Coenzyme A carboxylase alpha, Acetyl Coenzyme A carboxylase beta, Biotin carboxylase, COA1, COA2, HACC275, OTTHUMP00000164069, OTTHUMP00000164070, OTTHUMP00000164076, OTTHUMP00000240532 antibody

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within Human Acetyl CoA Carboxylase 1 (ACC1) aa 1150-1400.

Purification & Purity:

Protein affinity purified.

Molecular weight:

265 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

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