Background:

ABCF1 (ATP-binding cassette sub-family F member 1, TNF-alpha-stimulated ABC protein) is a 845 amino acid protein encoded by the human gene ABCF1. ABCF1 belongs to the ABC transporter family (EF3 subfamily) and contains two ABC transporter domains. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. ABCF1 is believed to have a role in mRNA translation due to its interaction with eukaryotic initiation factor 2 (eIF2). It is also associated with ribosomes. ABCF1 is ubiquitously expressed and can be induced with TNF. Upon DNA damage, ABCF1 is phosphorylated by either ATM or ATR.

Specificity:

ABCF1 polyclonal antibody detects endogenous levels of ABCF1 protein.

Alternative names:

ABCF1, ABC27, ABC50, ABCF1, ABCF1, ATP binding cassette 50 (TNF alpha stimulated), ATP binding cassette 50, ATP binding cassette sub family F member 1, ATP binding cassette, sub family F (GCN20), member 1, ATP-binding cassette 50, ATP-binding cassette sub-family F member 1, AU041969, D17Wsu166e, EST123147, GCN20, TNF alpha stimulated ABC protein, TNF-alpha-stimulated ABC protein, TNFalpha inducible ATP binding protein, wu:fb79c06, wu:fc39a05, wu:fj94a08, zgc:85667,

Species reactivity:

Human, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

96 kDa

Applications:

WB ICC/IF IHC

Usage:

WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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