Background:

The nucleolus consists of a number of specific proteins that play a critical role in the assembly of ribosomes, as well as in the maintenance and structural integrity of the nucleolus. NSUN6 ( NOL1/NOP2/Sun domain family member 6), also known as NOPD1 (NOL1/NOP2/Sun and PUA domain-containing protein 1), is a 469 amino acid protein that belongs to the methyltransferase superfamily. NSUN6 contains 1 PUA domain and may have S-adenosyl-L-methionine-dependent methyl-transferase activity. The gene encoding NSUN6 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie-tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Specificity:

NSUN6 polyclonal antibody detects endogenous levels of NSUN6 protein.

Alternative names:

Putative methyltransferase NSUN6; NOL1/NOP2/Sun and PUA domain-containing protein 1; NOL1/NOP2/Sun domain family member 6; NSUN6; NOPD1

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human NSUN6.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 52kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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