Background:

Cells undergoing apoptosis lose the asymmetry of plasma membrane phospholipids, and phosphatidylserine is exposed on the outer surface of the membrane. The phosphatidylserine receptor (PSR) specifically recognizes phosphatidylserine and this binding triggers the phagocytosis of apoptotic cells by either macrophages or dendritic cells. PSR is expressed on the surface of macrophages, fibroblasts, and epithelial cells, and it has been detected in high levels in heart, skeletal muscle, and kidney tissues and is extensively glycosylated. The mammalian phosphatidylserine receptor displays significant homology to Caenorhabditis elegans and Drosophila melanogaster proteins, which suggests that PSR has been conserved throughout phylogeny.

Specificity:

JMJD6 polyclonal antibody detects endogenous levels of JMJD6 protein.

Alternative names:

PSR; PTDSR; PTDSR1; KIAA0585; jumonji domain containing 6; Lysyl-hydroxylase JMJD6; Phosphatidylserine receptor; PTDSR; KIAA0585; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; PSR; Peptide-lysine 5-dioxygenase JMJD6; Protein PTDSR

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human JMJD6.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 46kDa

Applications:

WB,IHC,IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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