Background:

Members of the NFκB family of transcription factors are important in regulating the expression of various cellular and viral genes involved in immune and inflammatory responses, cell survival and stress responses. IL-1, TNFα and other related signaling pathways activate transcription factors through the activation of JNK. The NFκB signaling pathway converges with the signal-induced activation of JNK upstream of IKK. Isolated from the human embryonic kidney (HEK) 293 cell line, Act1 is an IKKγ-associated protein that activates both NFκB and JNK constitutively. Act1, also designated NFκB activator 1 or CIKS (for connection to IKK and SAPK/JNK), may function as a coordinator between two stress-induced signaling pathways.

Specificity:

TRAF3IP2 polyclonal antibody detects endogenous levels of TRAF3IP2 protein.

Alternative names:

Adapter protein CIKS; Connection to IKK and SAPK/JNK; Nuclear factor NF-kappa-B activator 1; ACT1; TRAF3-interacting protein 2; TRAF3IP2; C6orf2; C6orf4; C6orf5; C6orf6

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human TRAF3IP2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 65 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com