Background:

Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments . A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments . Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans. TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively. TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 . The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein . The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B.

Specificity:

TMOD4 polyclonal antibody detects endogenous levels of TMOD4 protein.

Alternative names:

Tropomodulin-4; Skeletal muscle tropomodulin; Sk-Tmod; TMOD4

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human TMOD4.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 39 kDa

Applications:

WB IHC IF

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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