Background:

QPCT (glutaminyl-peptide cyclotransferase) is a 361 amino acid protein that belongs to the glutaminyl-peptide cyclotransferase family. QPCT is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. QPCT binds one zinc ion per subunit and has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue. The human QPCT gene shares 86% overall sequence identity with the bovine homolog. QPCT contains an N-terminal signal peptide region, several glycosylation and phosphorylation sites and two cysteine residues conserved between the bovine and human enzymes. Existing as two alternatively spliced isoforms, the QPCT gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, fruit fly, mosquito, M.grisea and N.crassa, and maps to human chromosome 2p22.2.

Specificity:

QPCT polyclonal antibody detects endogenous levels of QPCT protein.

Alternative names:

Glutaminyl-peptide cyclotransferase; Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC; QPCT

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human QPCT.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 41 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

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