Background:

Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.

Specificity:

PROK2 polyclonal antibody detects endogenous levels of PROK2 protein.

Alternative names:

Prokineticin-2; PK2; Protein Bv8 homolog; PROK2; BV8

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human PROK2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 14 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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