Background:

Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. Two different genes, MAT1A and MAT2A, encode a liver specific and non-liver specific form of MAT, designated MAT Iα and MAT IIα, respectively. Inactivation of the liver specific gene product, designated MAT I/III, associates with liver diseases such as cirrhosis. MAT Iα expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT IIα present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NF-kB and TNFα cause a switch from MAT Iα to MAT IIα expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth.

Specificity:

MAT1A polyclonal antibody detects endogenous levels of MAT1A protein.

Alternative names:

S-adenosylmethionine synthase isoform type-1; AdoMet synthase 1; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III; MAT1A; AMS1; MATA1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human MAT1A.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 44 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com