Background:

Hyaluronidases (HAases or HYALs) are a family of lysosomal enzymes that are crucial for the spread of bacterial infections and of toxins present in a variety of venoms. HYALs may also be involved in the progression of cancer. In humans, six HYAL proteins have been identified. Most HYAL proteins degrade hyaluronic acid (HA), which is present in body fluids, tissues and the extracellular matrix of vertebrate tissues. HA keeps tissues hydrated, maintains osmotic balance and promotes cell proliferation, differentiation and metastasis. HA is also an important structural component of cartilage and other tissues and acts as a lubricant in joints. HYAL1 is a 435 amino acid hyaluronidase that is is expressed in multiple tissues, specifically in the serum, and is not expressed in brain. HYAL1 degrades HA into into fragments that stimulate angiogenesis. Expression of HYAL1 in various cancer cells may have a role in the regulation of tumor growth and progression.

Specificity:

HYAL1 polyclonal antibody detects endogenous levels of HYAL1 protein.

Alternative names:

Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; HYAL1; LUCA1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human HYAL1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 48 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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