Background:

GPAM (glycerol-3-phosphate acyltransferase, mitochondrial), also known as GPAT1, GPAT or KIAA1560, is an 828 amino acid multi-pass membrane protein that localizes to the outer membrane of the mitochondria and is involved in phospholipid metabolism. More specifically, GPAM functions to catalyze the first and committing step in the biosynthesis of glycerolipid, namely the conversion of Acyl-CoA and sn-glycerol 3-phosphate to CoA and 1-acyl-sn-glycerol 3-phosphate. Via its catalytic activity, GPAM plays an essential role in the regulation of cellular triacylglycerol and phospholipid levels. The gene encoding GPAM maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Specificity:

GPAM polyclonal antibody detects endogenous levels of GPAM protein.

Alternative names:

Glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT-1; GPAM; GPAT1; KIAA1560

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human GPAM.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 94 kDa

Applications:

WB,IHC

Usage:

WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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