Background:

M-ficolin, also known as ficolin-A, ficolin-1, ficolin-α, FCN1, FCNM or collagen/fibrinogen domain containing protein 1, is a 326 amino acid member of the ficolin lectin family. Characteristic of ficolin family proteins, M-ficolin contains a short N-terminus, one collagen-like domain and one fibrinogen-like domain at its C-terminus. M-ficolin is a secreted innate immunity pattern recognition molecule predominantly expressed in peripheral blood leukocytes. It is believed to function as a plasma protein and is known to interact with elastin, carbohydrates and corticosteroids. M-ficolin exists as a homopolymer through intermolecular disulfide bonding and is involved in activating lectin activity via association with MASPs and specific carbohydrate ligands.

Specificity:

FCN1 polyclonal antibody detects endogenous levels of FCN1 protein.

Alternative names:

Ficolin-1; Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin; FCN1; FCNM

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human FCN1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 35 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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