Background:

Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. Bcl-2 is one of many key regulators of apoptosis that are essential for proper development, tissue homeostasis and protection against foreign pathogens. Bcl-G, also known as BCL2L14 (BCL2-like 14) or BCLG, is a 327 amino acid cytoplasmic protein that belongs to the Bcl-2 family of apoptosis-regulating proteins. Bcl-G is expressed as three alternatively spliced transcripts designated short, medium and long. The short isoform is testis-specific and localizes to cytosolic organelles, while the long isoform is widely expressed and is distributed throughout the cytosol. Overexpression of Bcl-G induces apoptosis in cells, suggesting a possible role for Bcl-G in tumor suppression.

Specificity:

BCL2L14 polyclonal antibody detects endogenous levels of BCL2L14 protein.

Alternative names:

Apoptosis facilitator Bcl-2-like protein 14; Bcl2-L-14; Apoptosis regulator Bcl-G; BCL2L14; BCLG

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human BCL2L14.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 37 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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