Background:

SEPHS1 (selenophosphate synthetase 1), also known as SELD, SPS or SPS1, is a 392 amino acid member of the selenophosphate synthetase 1 family and is one of two mammalian homologs of the eubacteria selenophosphate synthetase protein SelD. SelD is an enzyme that generates the selenium donor for the biosynthesis of selenocysteine, an amino acid that is co-translationally incorporated into selenoproteins at in-frame UGA codons. SEPHS1 has a similar function to SelD and specifically catalyzes the formation of selenophosphate (the active selenium donor) from selenide, ATP and H2O. Proper SEPHS1 function depends on a selenium salvage system that recycles L-selenocysteine, thereby providing the substrates for selenophosphate synthesis.

Specificity:

SEPHS1 polyclonal antibody detects endogenous levels of SEPHS1 protein.

Alternative names:

Selenide, water dikinase 1; Selenium donor protein 1; Selenophosphate synthase 1; SEPHS1; SELD; SPS; SPS1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human SEPHS1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 43 kDa

Applications:

WB IF

Usage:

WB 1:500 - 1:2000 IF 1:50 - 1:100

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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