Background:

BAP29 (BCR-associated protein 29), also known as BCAP29 (B-cell receptor-associated protein 29), is a multi-pass membrane protein localizing to the endoplasmic reticulum (ER) and belonging to the BCAP29/BCAP31 family of proteins. It is ubiquitously expressed with predominant expression in brain and testis. BAP29 contains a hydrophobic N-terminus, three transmembrane domains, a coiled-coil region and a C-terminal double-lysine motif that is implicated in vesicular transport. BAP29 exists as a homodimer or as a heterodimer with BAP31 and plays a role in membrane IgD molecule retention in the ER. In addition, the BAP29/BAP31 complex functions as a cargo receptor for MHC class I molecules and is important for recruiting the class I molecules to exit sites of the ER. The BAP29/BAP31 complex is also essential for proper trafficking from the ER to the Golgi.

Specificity:

BCAP29 polyclonal antibody detects endogenous levels of BCAP29 protein.

Alternative names:

B-cell receptor-associated protein 29; BCR-associated protein 29; Bap29; BCAP29; BAP29

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human BCAP29.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 28 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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