Background:

DHRS9 (dehydrogenase/reductase (SDR family) member 9), also known as RDHL, RDH15, RDHTBE, SDR9C4 or RETSDR8, is a 319 amino acid protein that localizes to the membrane of both the microsome and the endoplasmic reticulum and belongs to the short-chain dehydrogenase/reductase family. Expressed at high levels in trachea and epidermis and present at lower levels in brain, colon, heart, lung, testis, placenta and skeletal muscle, DHRS9 functions as a homotetramer that converts both 3-alpha-tetrahydroprogesterone (allopregnanolone) and 3-alpha-androstanediol to dihydroxyprogesterone and is thought to play a role in retinoic acid biosynthesis. Multiple isoforms of DHRS9 exist due to alternative splicing events.

Specificity:

DHRS9 polyclonal antibody detects endogenous levels of DHRS9 protein.

Alternative names:

Dehydrogenase/reductase SDR family member 9; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; RDHL; Short-chain dehydrogenase/reductase retSDR8; Tracheobronchial epithelial cell-specific retinol dehydrogenase; RDH-TBE; DHRS9; UNQ835/PRO1773

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human DHRS9.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 35 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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