Background:

Thioredoxins are small redox active proteins that play a variety of roles throughout the cell. TXNL1 (Thioredoxin-like protein 1), also known as TRP32, TXL or TXL-1, is a 289 amino acid cytoplasmic protein that is thought to participate in endocytotic signaling pathways and may act as a redox sensor. Expressed throughout the body, TXNL1 functions to couple oxidative stress to endocytosis, thereby regulating the GDI:Rad5-mediated endocytic response. Additionally, overexpression of TXNL1 inhibits cell proliferation by predisposing the cell to G0/G1 arrest, suggesting that TXNL1 also functions as a transcriptional repressor. TXNL1 shares 99% homology with its mouse homolog and contains one thioredoxin domain.

Specificity:

TXNL1 polyclonal antibody detects endogenous levels of TXNL1 protein.

Alternative names:

Thioredoxin-like protein 1; 32 kDa thioredoxin-related protein; TXNL1; TRP32; TXL; TXNL

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant TXNL1 protein, corresponding to amino acids 1-289 of Human LGR5.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 32 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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