Background:

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicty constitutes an important component of specific effector mechanisms in immuno- surveillance against virus-infected or -transformed cells. One mechanism for this activity involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercelluler interactions of FAS with its ligand or effectors, and may be critically involved in CTL-mediated cytoxicity. Toso was identified as a cell surface protein that is expressed in lymphoid cells. Toso blocks apoptosis mediated by members of the TNF family, including FAS, and has been shown to inhibit TCR induced T cell self-killing.

Specificity:

FAIM3 polyclonal antibody detects endogenous levels of FAIM3 protein.

Alternative names:

Fas apoptotic inhibitory molecule 3; Regulator of Fas-induced apoptosis Toso; FAIM3; TOSO

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human FAIM3.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 43 kDa

Applications:

WB,IF

Usage:

WB 1:500 - 1:2000 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com