Background:

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of poly-peptides that contribute to mRNA transcription and pre-mRNA processing, as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which is the transcript produced by RNA polymerase II. There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome. The majority of hnRNP protein components are localized to the nucleus; however, some shuttle between the nucleus and the cytoplasm. Two abundant and ubiquitously expressed members of the hnRNP family are hnRNP D0 and hnRNP R. Specifically, the hnRNP D0 protein contains two RNA-binding domains (RBDs), which bind to both RNA and DNA sequences. hnRNP D0 also possesses a transactivator domain and is involved in transcriptional regulation.

Specificity:

HNRNPR polyclonal antibody detects endogenous levels of HNRNPR protein.

Alternative names:

Heterogeneous nuclear ribonucleoprotein R; hnRNP R; HNRNPR; HNRPR

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human HNRNPR.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 71 kDa

Applications:

WB IHC IF

Usage:

WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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