Background:

Brother of the regulator of imprinted sites (BORIS) is a mammalian transcription factor that is paralogous to the CCCTC-binding factor (CTCF), an ubiquitous 11 zinc finger (ZF) protein that organizes epigenetically controlled chromatin insulators that regulate imprinted genes in soma. BORIS is a 663 amino acid DNA binding protein. It is expressed at high levels in the testis and in low levels in the prostate in a mutually exclusive pattern that correlates with the re-setting of methylation marks during male germ cell differentiation. Abnormal expression of BORIS is linked to many types of cancer including breast, pro-state, ovary, gastric, liver, endometrial, glia, colon and esophagus.

Specificity:

CTCFL polyclonal antibody detects endogenous levels of CTCFL protein.

Alternative names:

BORIS like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC binding factor (zinc finger protein) like; CCCTC-binding factor; CT27; CTCF paralog; CTCF T; CTCF-like protein; Ctcfl; CTCFL_HUMAN; dJ579F20.2; HMG 1L1; HMGB1L1; MGC163358; MGC169105; MGC169106; Putative high mobility group protein 1 like 1; Putative high mobility group protein B1 like 1; Transcriptional repressor CTCFL; Zinc finger protein CTCF-T;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human CTCFL.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 75 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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