Background:

Twinfilin-2, also known as TWF2, A6r, A6RP or PTK9L, is a 349 amino acid protein that localizes to the perinuclear region of the cytoplasm, as well as to the cytoskeleton, and contains two ADF-H domains. Expressed ubiquitously, Twinfilin-2 functions as an Actin-binding protein that is able to both bind and sequester G-Actin and cap the barbed ends of Actin filaments, thereby inhibiting Actin polymerization and playing a role in Actin-related motile and morphological processes. Twinfilin-2 is subject to post-translational phosphorylation by PKC zeta. The gene encoding Twinfilin-2 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Specificity:

TWF2 polyclonal antibody detects endogenous levels of TWF2 protein.

Alternative names:

A6 related protein; A6-related protein; A6r; A6RP; hA6RP; MSTP011; Protein tyrosine kinase 9 like; Protein tyrosine kinase 9-like; PTK 9L; PTK9L; PTK9L protein tyrosine kinase 9 like; TWF 2; Twf2; TWF2_HUMAN; Twinfilin 1 like protein; Twinfilin 2; Twinfilin actin binding protein homolog 2; Twinfilin like protein; Twinfilin-1-like protein; Twinfilin-2; Twinfilin2;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human TWF2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 39 kDa

Applications:

WB IHC IP

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:20 - 1:50

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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