Background:

PRMT2 (Protein arginine N-methyltransferase 2) is a 433 amino acid protein encoded by the human gene PRMT2. PRMT2 belongs to the protein arginine N-methyltransferase family and contains one SH3 domain. The primary function of protein methyltransferases is the post-translational methylation of arginine residues. The PRMT family of proteins contains related putative methyltransferase domains that modify chromatin and regulate cellular transcription. Some family members, PRMT1 and PRMT4, show transcriptional modulation and intracellular signaling. Through a highly conserved S-adenosylmethionine-binding domain, PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis. PRMT2 has this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, which increases nuclear IkappaB-alpha and decreases NF-kappaB DNA binding. PRMT2 also renders cells susceptible to apoptosis by cytokines or cytotoxic drugs.

Specificity:

PRMT2 polyclonal antibody detects endogenous levels of PRMT2 protein.

Alternative names:

ANM2_HUMAN; EC 2.1.1.; histone arginine N methyltransferase PRMT2; Histone-arginine N-methyltransferase PRMT2; HMT 1; HMT1 (hnRNP methyltransferase S. cerevisiae) like 1; HMT1; HMT1 hnRNP methyltransferase like 1; hnRNP methyltransferase (S. cerevisiae) like 1; hnRNP methyltransferase like 1; Hrmt1l1; MGC111373; PRMT 2; PRMT2 alpha; prmt2; PRMT2 beta; PRMT2 gamma; PRMT2 protein; PRMT2L2; Protein arginine methyltransferase 2; Protein arginine N methyltransferase 2; Protein arginine N-methyltransferase 2; Zf2;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human PRMT2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 49 kDa

Applications:

WB IHC IF

Usage:

WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com