Background:

ALR (augmenter of liver regeneration), also called Erv1-like growth factor, hepatopoietin (HPO) or hepatic regenerative stimulation substance (HSS), is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase expressed in various tissues. ALR exists as a homodimer and belongs to the Erv1/ALR family of proteins. This family can be found in higher and lower eukaryotes. ALR has two forms: a cytosolic form and a nuclear form. The nuclear form regulates the transcriptional activity of AP-1. The cytosolic form plays a role in the biogenesis of Fe/S proteins and contributes to cellular iron homeostasis. In addition, ALR induces the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylase (ODC), which each play an important role in the synthesis of polyamines. Through stimulation of polyamine synthesis, ALR heavily contributes to the regulation of the different stages of liver regeneration.

Specificity:

GFER polyclonal antibody detects endogenous levels of GFER protein.

Alternative names:

ALR_HUMAN; Augmenter of Liver Regeneration; ERV1 homolog; FAD-linked sulfhydryl oxidase ALR; GFER; Growth factor erv1 like; Hepatopoietin; hERV; hERV1; HPO;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human GFER.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 23 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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