Background:

Regulation of intracellular concentrations of flavoenzymes and flavin coenzymes is essential for proper cell homeostasis. Red cell acid phosphatase, known as ACP1, catalyzes the transfer of phosphate from phosphate ester substrates to suitable acceptor alcohols such as methanol and glycerol. ACP is a genetically polymorphic, cytoplasmic low-molecular-weight flavin mononucleotide phosphatase that regulates the intracellular concentrations of flavin coenzymes. The human ACP1 gene maps to chromosome 2p25 and encodes a pair of isozymes, Bf (alpha) and Bs (beta). The ACP1 alpha and beta isozymes are not glycosylated. Both ACP1-alpha and ACP1-beta isozymes are 157 amino acids in length; however the two forms differ in sequence over an internal 34 residue segment. The two isoforms are believed to differ in substrate specificity.

Specificity:

ACP1 polyclonal antibody detects endogenous levels of ACP1 protein.

Alternative names:

Acid phosphatase 1 soluble; Acid phosphatase of erythrocyte; ACP1; Adipocyte acid phosphatase; Cytoplasmic phosphotyrosyl protein phosphatase; HAAP; LMW-PTP; LMW-PTPase; Low molecular weight cytosolic acid phosphatase; Low molecular weight phosphotyrosine protein phosphatase; PAP1; PAP2; PPAC_HUMAN; Protein tyrosine phosphatase; PTPase; Purple acid phosphatase; Red cell acid phosphatase 1;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human ACP1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 18 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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