Background:

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Specificity:

KIR2DS4 polyclonal antibody detects endogenous levels of KIR2DS4 protein.

Alternative names:

CD158 antigen like family member I; CD158 antigen-like family member I; CD158i; CD158i antigen; CL 17; CL 39; CL17; CL39; KI2S4_HUMAN; Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 4; Killer cell immunoglobulin-like receptor 2DS4; Killer inhibitory receptor 4 1 2; KIR antigen 2DS4; KIR1D; KIR2DS4; KIR412; KKA3; MGC120019; MGC125315; MGC125317; MHC class I NK cell receptor; Natural killer associated transcript 8; Natural killer cell inhibitory receptor; Natural killer-associated transcript 8; NKAT 8; NKAT-8; NKAT8; OTTHUMP00000199030; P58 natural killer cell receptor clone CL 39; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor; p58 NK receptor CL-39/CL-17;

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human KIR2DS4.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 34 kDa

Applications:

WB IF

Usage:

WB 1:500 - 1:2000 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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