Background:

T cell leukemia/lymphoma protein 1B (TCL-1B), also designated TML1, TCL/MTCP1-like 1, syncytiotrophoblast-specific protein and SYN-1, is involved in T cell prolymphocytic leukemia (T-PLL). TCL-1B is located within the region on human chromosome 14q32.1 which, in T cell leukemias and lymphomasis, is frequently involved in chromosomal translocations and inversions with one of the T cell receptor loci. TCL-1B is activated by chromosomal rearrangements involving the TCL1 locus. In mouse, TCL-1B is represented by five homologues, TCL-1B1-TCL-1B5. The crystal structure of TCL-1B suggests that it may play a role in the transport of small molecules such as retinoids, nucleotides and fatty acids. TCL-1B is found in both the nucleus and the cytoplasm of normal bone marrow and peripheral lymphocytes.

Specificity:

TCL1B polyclonal antibody detects endogenous levels of TCL1B protein.

Alternative names:

SYN-1; TML1

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human TCL1B

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

15kDa

Applications:

WB,IF

Usage:

WB 1:500 - 1:2000 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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