Background:

Substance P (SP) and neurokinin-A (NK-A) are members of the tachykinins, and they function as modulators of the immune and hematopoietic systems. The tachykinins interact with each of three cloned neurokinin (NK) receptors (NK-1R, NK-2R, NK-3R), with SP and NK-A exhibiting binding preferences for NK-1R and NK-2R, respectively. NK-4R shares close homology with NK-3R, and both have nearly identical pharmacologicl properties. In the normal ileum and colon, NK-1R and NK-2R are localized to smooth muscle cells of the muscularis mucosae and propria and to a few inflammatory cells of the lamina propria. NK-1R expression is also found in the muscular wall of submucosal blood vessels, enteric neurons and, to a lesser degree, in surface epithelial cells. NK-3R is found in the spinal cord in both lamina X and lamina II.

Specificity:

NK-3R polyclonal antibody detects endogenous levels of NK-3R protein.

Alternative names:

Neuromedin-K receptor; NKR; NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3; TACR3; NK3R; TAC3R

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human TACR3

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

52kDa

Applications:

WB IHC

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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