Background:

CEP164 (Centrosomal protein of 164 kDa) is a 1,460 amino acid protein that plays a critical role in G2/M checkpoint and nuclear divisions by maintaining the formation of primary cilia. CEP164 is required for proper phosphorylation of Chk1, Chk2, Histone H2A and RPA and is therefore an essential player in the DNA-damage-activated ATR/ATM signaling cascade. Localized to the centrioles throughout mitosis, CEP164 also is required for the maintenance of genomic stability and chromosomal segregation. There are two isoforms of CEP164 that are produced as a result of alternative splicing events.

Specificity:

CEP164 polyclonal antibody detects endogenous levels of CEP164 protein.

Alternative names:

KIAA1052; NPHP15; Centrosomal protein of 164 kDa

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human CEP164.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 164 kDa

Applications:

WB IHC

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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