Background:

ANKH (progressive ankylosis protein homolog) is a multi-pass transmembrane protein involved in bone mineralization and joint maintenance. ANKH is a ubiquitously expressed protein with high expression levels in the embryonic developing articular cartilage of joints in the elbow, wrist, shoulders and digits. Expression of ANKH is regulated by cytokines and various growth factors. ANKH functions as a transporter, regulating the extracellular transport of inorganic pyrophosphates (PPi). The extracellular level of inorganic pyrophosphates can both inhibit and promote different types of pathologic mineralization. Mutations in ANKH are associated with various human skeletal defects including calcium pyrophosphate deposition disease (CPPD) and craniometaphyseal dysplasia Jackson type (CMDJ).

Specificity:

ANKH polyclonal antibody detects endogenous levels of ANKH protein.

Alternative names:

Progressive ankylosis protein homolog; ANK; KIAA1581; UNQ241/PRO274

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human ANKH.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 54 kDa

Applications:

WB IHC

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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