Background:

COL9A3 (also known as Collagen α3 Type IX) belongs to the fibril-associated collagens with interrupted helices (FACIT) family. COL9 is expressed in cartilage, cornea and in the vitreous portion of the eye and is a heterotrimer composed of COL9A1 and COL9A2. When expressed in hyaline cartilage, COL9 posseses a large N-terminal globular domain (NC4). Mutations in the COL9A3 gene are associated with multiple epiphyseal dysplasia (MED), a chondrodysplasia, in humans. COL9 is often co-localized with COL2A1, and may play a role in the interaction of fibrils between COL2A1 and COL9.

Specificity:

COL9A3 polyclonal antibody detects endogenous levels of COL9A3 protein.

Alternative names:

Collagen alpha-3(IX) chain

Species reactivity:

Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human COL9A3.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 64 kDa

Applications:

IHC

Usage:

IHC 1:100 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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