Background:

NUDT15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15), also known as MTH2, is a 164 amino acid protein that belongs to the nudix hydrolase family and uses magnesium as a cofactor to catalyze the conversion of 8-oxo-dGTP to 8-oxo-dGMP and diphosphate. Via its catalytic activity, NUDT15 mediates the hydrolysis of select nucleoside diphosphate derivatives and may play a role in the prevention of DNA transversions. The gene encoding NUDT15 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.

Specificity:

NUDT15 polyclonal antibody detects endogenous levels of NUDT15 protein.

Alternative names:

MTH2; Probable 8-oxo-dGTP diphosphatase NUDT15

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human NUDT15.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 19 kDa

Applications:

WB IHC

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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