Background:

PITRM1 (pitrilysin metallopeptidase 1), also known as MP1, PreP, hMP1, KIAA1104, MGC138192 or MGC141929, is a 1,037 amino acid protein belonging to the peptidase M16 family and the PreP subfamily. Encoded by a gene that maps to human chromosome 10p15.2, PITRM1 is widely expressed, with higher levels in muscle and heart compared to brain, pancreas, liver, lung and placenta. PITRM1 is an ATP-independent protease that degrades mitochondrial transit peptides and other unstructured peptides after cleavage. PITRM1 also degrades Amyloid A4 proteins in mitochondrion, suggesting a link with Alzheimer disease. PITRM1 exists as two alternatively spliced isoforms and is specific for peptides in the range of 10 to 65 residues.

Specificity:

PITRM1 polyclonal antibody detects endogenous levels of PITRM1 protein.

Alternative names:

hPreP; Pitrilysin metalloproteinase 1; Metalloprotease 1; MP1; KIAA1104; MP1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human PITRM1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 117 kDa

Applications:

WB,IHC,IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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