Background:

SETD3 (SET domain containing 3) is a 594 amino acid protein that belongs to the SETD3 family. Containing one SET domain and localizing to nucleus, SETD3 is a histone methyltransferase that methylates Lys 36 of Histone H3. Overexpression of the setd3 protein in zebrafish decreases cell viability and activates caspase-3, indicating possible roles in apoptotic cell death and cell cycle regulation. In zebrafish the setd3 protein is composed of 17 α-helices and 8 β-sheets in the secondary structures.

Specificity:

SETD3 polyclonal antibody detects endogenous levels of SETD3 protein.

Alternative names:

C14orf154; Histone-lysine N-methyltransferase setd3; SET domain-containing protein 3

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide of human SETD3.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 67 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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