Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
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RecombinantI-TAC/CXCL11,Human BK0114

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Specifications

size	10μg / 50μg / 1mg

Source:

Escherichia coli.

Molecular Weight:

8.4 kDa, observed by reducing SDS-PAGE.

Purity:

> 95% as analyzed by SDS-PAGE and HPLC.

Biological activity:

ED50 < 2.5 µg/mL, measured by the FLIPR assay using CHO cells transfected with human CXCR3, the receptor of human CXCL11, corresponding to a specific activity of > 400 units/mg.

AA Sequence:

MFPMFKRGR CLCIGPGVKA VKVADIEKAS IMYPSNNCDK IEVIITLKEN KGQRCLNPKS KQARLIIKKV ERKNF

Endotoxin:

< 0.2 EU/μg, determined by LAL method.

Formulation:

Lyophilized after extensive dialysis against PBS.

Background:

I-TAC (Interferon-inducible T-cell α Chemoattractant), also known as CXCL11, is a chemokine belonging to the CXCL subfamily. Along with Interferon-γ induced Protein 10 kDa and Monokine Induced by Interferon-γ, I-TAC is strongly up-regulated by Interferon-γ and binds to the G-protein coupled receptor CXCR3. The expression of CXCR3 is associated with Th1-mediated immune responses and mediates chemotaxis of Th1 cells. I-TAC induces, maintains, and amplifies the inflammatory reactions, and sustains chronic immune responses against self-antigens. Although CXCR3 was thought to be the exclusive receptor of I-TAC initially, more evidence has shown that I-TAC can also bind to CXCR4 and CXCR7, and that I-TAC plays important roles in tumor development and angiostasis. Recombinant human I-TAC/CXCL11 (rhI-TAC) produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-TAC has a molecular mass of 8.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.

Usage:

This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.

Physical Appearance:

Sterile Filtered White lyophilized (freeze-dried) powder.

Reconstitution:

Reconstituted in ddH2O at 100 μg/mL.

Storage:

Lyophilized recombinant human I-TAC/CXCL11 (rhI-TAC) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhI-TAC remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.