CD40 Rabbit mAb (AMR12837N) AMR12837N

Product info:

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names:

CD40; Bp50; CDW40; TNFRSF5; p50

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Cell membrane, Secreted, Single-pass type I membrane protein

Isotype:

IgG

Immunogen:

Recombinant protein of human CD40

Positive control:

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AA Sequence:

Email info@sobekbio.com for sequence

Purification:

Affinity purification

Molecular weight:

Calculated MW: 22kDa/30kDa Observed MW: Refer to figures

Form:

Liquid

Applications:

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Dilution:

ELISA 1:500 - 1:2000 WB 1:500 - 1:2000 FC 1:50 - 1:200 IF 1:50 - 1:200

Storage buffer:

Buffer: PBS with 0.02% thimerosal, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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