[KO Validated] Lamin A/C Rabbit mAb (AMR11251N) AMR11251N

Product info:

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Alternative names:

LMNA; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1; lamin; Lamin A/C

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Cellular localisation:

Nucleus, Nucleus envelope, Nucleus lamina, Nucleus speckle, nucleoplasm

Isotype:

IgG

Immunogen:

Recombinant protein of human Lamin A/C.

Positive control:

K-562, A-549, NIH/3T3, Rat lung, HeLa, HeLa whole cell protein, HeLa cytoplasm protein, HeLa nuclear protein, NIH/3T3 whole cell protein, NIH/3T3 cytoplasm protein, NIH/3T3 nuclear protein, C6 whole cell protein, C6 cytoplasm protein, C6 nuclear protein

AA Sequence:

Email info@sobekbio.com for sequence

Purification:

Affinity purification

Molecular weight:

Calculated MW: 62-74kDa Observed MW: 62kDa/74kDa

Form:

Liquid

Applications:

WB (Mus musculus)

Dilution:

WB 1:50000 - 1:200000 IHC 1:50 - 1:1000 IF 1:50 - 1:1000 IP 1:50 - 1:200

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com